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HSD17B13-IN-24 (41) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-43 (11) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-25 (43) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-34 (75) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-37 (78) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-62 (141) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-78 (22) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-58 (96) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-89 (206) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-85 (186) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-84 (182) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-90 (4) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
TC HSD 21 is a potent 17β-hydroxysteroiddehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors .
HSD17B13-IN-9 (252) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of 0.01 μM for 50 nM HSD17B13. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-95 (1) is an inhibitor of 17β-hydroxysteroiddehydrogenase(HSD17B13), and its IC50 value for estradiol is <0.1 μM. It can be used in the study of nonalcoholic fatty liver disease .
HSD17B13-IN-96 (3) is an inhibitor of 17β-hydroxysteroiddehydrogenase(HSD17B13), and its IC50 value for estradiol is <0.1 μM. It can be used in the study of nonalcoholic fatty liver disease .
HSD17B13-IN-98 (5) is an inhibitor of 17β-hydroxysteroiddehydrogenase(HSD17B13), and its IC50 value for estradiol is <0.1 μM. It can be used in the study of nonalcoholic fatty liver disease .
HSD17B13-IN-62-d3 (176) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-80-d3 (179) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-8 (1) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with IC50 values of <0.1 μM for Estradiol and <1 μM for LTB3. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroiddehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .
Steroidsulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroiddehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroidsulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases .
HSD17B13-IN-101 is a selective inhibitor of 17β-hydroxysteroiddehydrogenase(HSD17B13), and its IC50 value for Estradiol is <0.1 μM. HSD17B13-IN-101 can be used in the study of nonalcoholic fatty liver disease (NAFLD) (WO2023146897A1; compound 94) .
AZD8329 is a potent 11β-Hydroxysteroiddehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3 .
17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor，targeting to 17β-hydroxysteroiddehydrogenase type 10 (17β-HSD10)，a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer .
Steroidsulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroiddehydrogenase type 1 (17β HSD1). Steroidsulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroidsulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases .
Steroidsulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroiddehydrogenase type 1 (17β HSD1). Steroidsulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroidsulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases .
Steroidsulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroidsulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroiddehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroidsulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research .
11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroiddehydrogenase (11βHSD) isozymes inhibitor[1][2].
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroiddehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .
11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroiddehydrogenase (11βHSD) isozymes inhibitor [1][2]
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroiddehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroiddehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism .
17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor，targeting to 17β-hydroxysteroiddehydrogenase type 10 (17β-HSD10)，a multifunctional mitochondrial enzyme. 17β-HSD10-IN-2 don't lead to mitochondrial off-targets and cytotoxic or neurotoxic effects. 17β-HSD10 inhibitors can be used for research in Alzheimer's disease (AD) and hormone-dependent cancer .
HSD17B13 Protein plays a pivotal role in hepatic lipid metabolism, actively contributing to the oxidation of diverse lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4. Demonstrating versatile catalytic activity in vitro, HSD17B13, notably, exhibits retinol/retinal dehydrogenase activity, emphasizing its potential impact on crucial pathways associated with lipid processing and metabolism. HSD17B13 Protein, Human (P.pastoris, His-Myc) is the recombinant human-derived HSD17B13 protein, expressed by P. pastoris , with N-His, C-Myc labeled tag. The total length of HSD17B13 Protein, Human (P.pastoris, His-Myc) is 281 a.a., with molecular weight of ~34.8 kDa.
HSD17B14 protein, with NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity, converts oestradiol to oestrone. Its enzymatic activity extends to both oestradiol and 5-androstene-3-beta,17-beta-diol in vitro, although the physiological substrate remains unidentified. HSD17B14 Protein, Human (HEK293, His) is the recombinant human-derived HSD17B14 protein, expressed by HEK293 , with C-His labeled tag. The total length of HSD17B14 Protein, Human (HEK293, His) is 270 a.a., with molecular weight of ~29.8 KDa.
11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroiddehydrogenase (11βHSD) isozymes inhibitor [1][2]
HSD17B13-IN-62-d3 (176) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
HSD17B13-IN-80-d3 (179) is a 17β-Hydroxysteroiddehydrogenases(HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research .
11-Beta-hydroxyandrostenedione-d4 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroiddehydrogenase (11βHSD) isozymes inhibitor[1][2].
